Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Chem. 3E-007 mm Hg (25 deg C, Mod-Grain method) Water Solubility Estimate from Log Kow (WSKOW v1.41): Water Solubility at 25 deg C (mg/L): 2912 log Kow used: -0.04 (expkow . Physical dangers . Theophylline | C7H8N4O2 | CID 2153 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. The solubility of satranidazole in several water-N,N-dimethylformamide mixtures was analysed in terms of solute-solvent interactions and data were treated on the basis of extended Hildebrand solubility approach. It is also moderately soluble in ethanol. Theophylline Supplier | CAS 58-55-9 | Tocris Bioscience Theophylline sodium glycinate. Theophylline | C7H8N4O2 - PubChem Measurement and Correlation of Solubility of Theobromine, Theophylline 1 ). The pH-solubility profiles of salicylic acid and theophylline, as determined by the addition of HCI or NaOH to their aqueous suspensions, were identical with those of their sodium salts except during phase transitions from acid to salt or vice versa. THEOPHYLLINE | CAMEO Chemicals | NOAA CA428272A - Water soluble theophylline derivative - Google Patents Join Free For Buyer. Spheroids - EP0270305B1 - Theophylline - Content determination. [Water soluble theophylline] G Med Mil. Home; About us; Membership & professional community . The solubility of theophylline in water is 5.5 mg/mL, whereas in methanol and ethanol is 0.699 mg/mL and 15.19 mg/mL,. The observed dissolution rate of theophylline monohydrate under various conditions agreed well with predictions based o Caffeine - Wikipedia - publixlogin.fluxus.org It is sparingly soluble in water and methanol, slightly soluble in glacial acetic acid and ethanol, and practically insoluble in ether. Membrane solubility parameter and in situ release of theophylline. National Center for Biotechnology Information. 2015/830 and US OSHA HCS 2015 . The cocrystal mole fraction solubility is calculated from the g/g measurement as the moles of the cocrystal 1:1 assembly (defined as 1 mole of THP and 1 mole of SA) per the total moles of the cocrystal 1:1 assembly and solvent. [Google Scholar] 10. Compared to the solubility in distilled water, a twofold increase in the aqueous . Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. However, theophylline is only sparingly soluble in water and alcohol. show through drawing chemical structure as well as drawing the electronic . . PubChem . PDF SAFETY DATA SHEET Page: 1 of 5 Theophylline Revision: Supersedes Revision National Institutes of Health. Theophylline is dimethylxanthine which is closely related chemically to caffeine (Fig. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is a bronchodilator, anti-inflammatory and immunomodulator. 1907/2006 as amended by (EC) No. The mole fraction solubility of satranidazole ( 2 =14.80) in PG ( 1 =14.80), water ( 1 =23.4), and in the mixture of the two solvents is represented . For batch specific data refer to the Certificate of Analysis. THEOPHYLLINE: ICSC: 0678: PHYSICAL & CHEMICAL INFORMATION; Physical State; Appearance WHITE CRYSTALLINE POWDER. Theophylline. Supersaturated solutions were formed during phase transitions. how? There was a strong synergistic effect of organic solvents . The logP value of theophylline is -0.02 giving the unionized form sufficient lipid solubility to diffuse passively through cell membranes. Effects of process variables on micromeritic properties and drug The interference of the hydrotropic agent in the analysis was found to be nil. Theophylline - Wikipedia Articles of Theophylline are included as well. Answered: aminophylline is a good water soluble | bartleby Theophylline | CAS#:58-55-9 | Chemsrc Symptoms may also include increased hunger, feeling tired, and sores that do not heal. a Performs postural drainage after meals b Supplements diet with water Dissolution of theophylline monohydrate and anhydrous theophylline in THEOPHYLLINE neutralizes acids in exothermic reactions to form salts plus water. Solvent Screening for Solubility Enhancement of Theophylline in Neat The mol fraction solubility of theophylline in propylene glycol/ water exhibits a maximum solubility of X^ = 5.9 X 10~3 at a solvent solubility parameter (oi) of ~ 14.2. all the products be . Supplements diet with water-soluble vitamins and fluids c. Plans a diet high in fat and calories d. Gives pancreatic enzymes before every meal and snack 124. take this product about 0.3g, precision weighing, add water 50ml, slightly dissolve, cool, add silver nitrate titration solution (0.lmol/L)25ml, plus bromothymol blue indicator solution 1ml, shake, with sodium hydroxide titration solution (0.1 mol/L) titration to a blue color of the solution. Spheroids - EP0270305A2 - The ideal solubility of anhydrous theophylline at 30 , calculated from the data of Fokkens et al. Soluble in: water, 1e+006 mg/L @ 25 C (est) Organoleptic Properties: Odor and/or flavor descriptions from others (if found). Soluble_Drug_Theophylline_Sodium_Glycina.pdf PDF i Thermodynamic Study on Hydrotropic Aggregation Behavior of Theophylline Solubility Notes: Soluble (slightly) in: MeOH; DMSO; Octanol/Water Partition Coefficient: No data. RJPT - New Quantitative Technique for estimation of solubility of A thermodynamic study of the solubility of theophylline and its hydrate Jump to main content Jump to site nav. chitosan oligosaccharide , water soluble chitosan, and high desity chitosan . March 3, 2010 Other authors Formulationand ln vitro Releaseof ICSC 0678 - THEOPHYLLINE - International Programme on Chemical Safety Solubility of theophylline in polar binary solvents. PDF Solvent Screening for Solubility Enhancement of Theophylline in Neat PDF Physical Properties and Crystallization of Theophylline Co-crystals Solubility Prediction of Satranidazole in Propylene Glycol-Water Expired Application number CA428272A Other languages Preliminary in situ (rat gut permeation) studies with the solvent mixtures having varying polarity as expressed by the solubility parameter showed that (a . soluble theophylline derivative water Prior art date 1945-06-19 Legal status (The legal status is an assumption and is not a legal conclusion. In the present study, hydrotropic solubilization technique has been used to solubilize the poorly water soluble anti-diuretic drugs such as theophylline for its spectrophotometric analysis. Pediatrics-Respiratory-RSV-isolation *Answer: Contact precautions 125. Theophylline - an overview | ScienceDirect Topics Theophylline is a weak acid (pKa 8.8). Theophylline SAFETY DATA SHEET Supersedes Revision: 12/03/2017 according to Regulation (EC) No. Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured at 25 C in a broad range of solvents, including neat, binary mixtures and ternary natural deep eutectics (NADES) prepared with choline chloride, polyols and water. Overmethylation Niacin Molecular mass: 180.2 Melting point: 270-274C Density: g/cm Solubility in water: moderate Vapour pressure: negligible Octanol/water partition coefficient as log Pow: -0.02 (estimated) EXPOSURE & HEALTH EFFECTS . Answered: aminophylline is a good water soluble | bartleby Process for increasing the solubility and dissolution rate of rutin, with the objective of improving absorption from the gastrointestinal tract, comprises the prodn. A quantitative approach is presented for predicting solubilities of crystalline compounds in binary solvent systems. aminophylline is a good water soluble derivative of theophylline as ethylene diamine derivative in order to enhance its water solubility for formulation options and to enhance the bioavailability of theophylline . Yongchao Su - Principal Scientist - Merck | LinkedIn The solubility of theophylline in mixed solvents consisting of dioxane and water was determined at 25 +/- 0.1 degrees. Effect of diffusion layer pH and solubility on the dissolution rate of Search: Ch3coch3 Hydrogen Bonding. Reactivity Profile. Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured at 25 C in a broad range of solvents, including neat, binary mixtures and ternary natural deep eutectics (NADES) prepared with choline chloride, polyols and water. Jul-Aug 1955;105(4):369-73. 0.8 mg/day for 5 to 8 days, single intravenous doses of digoxin 0.5 mg or theophylline 5 mg/kg resulted in no change in the pharmacokinetics of digoxin or theophylline. Call : 08037404927. Solubility Enhancement of Theophylline Drug Using Mixed Solvency High purity Theophylline 58-55-9 Suppliers,provide High purity Theophylline 58-55-9 product and the products related with China (Mainland) High purity Theophylline 58-55-9 CHANGCHUN WEIERSI IMPORT AND EXPORT TRADE CO.,LTD China (Mainland) . a This solubility decreases with increasing length of the carbon chain Answer: B Diff: 3 12) The HCN bond angle in hydrogen cyanide (HCN) is _____ The oxygen is more electro negative than hydrogen and hence the electrons are pulled towards the most electro negative element oxygen 1 . Theophylline dissolves in 1 M NH4OH at 50 mg/ml to yield a clear, colorless solution. Solubility Prediction of Satranidazole in Aqueous N,N-dimethylformamide Theophylline dissolves in 1 M NH4OH at 50 mg/ml to yield a clear, colorless solution. MeSH terms Theophylline* Water* Substances Water Theophylline . JOSHI AGROCHEM PHARMA PVT LTD. This chapter answers parts from Section B(ii) of the 2017 CICM Primary Syllabus, which expects the exam candidate to "Describe absorption and factors that will influence it". The effect of hydrate formation on the solubility of theophylline in A controlled release pharmaceutical composition comprising a plurality of film coated spheroids, the film coated spheroids comprising a 3-alkylxanthine, a non-water soluble spheronising agent and between 4% and 9% (by weight) water, wherein the in-vitro dissolution rate of the 3-alkylxanthine from the film coated spheroids, when measured by the USP Paddle Method at 100rpm in 900ml aqueous . View Soluble_Drug_Theophylline_Sodium_Glycina.pdf from PHARMACY 28 at KPJ University College , Nilai. The solubilities across this range of polar solvents were back-calculated using a technique involving an . However, the solubility of theophylline in water was Solubility of anhydrous theophylline in various solvents Martin A, Wu PL . Send Inquiry. Preparation and in vitro and in vivo characterization of novel forms of active pharmaceutical ingredients, suitable for pharmaceutical compositions in drug delivery systems for humans. It is used for bronchial asthma, preventing attacks, and systematic treatment. A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. B Joshi Agrochem Pharma - Manufacturer,Exporter,Supplier of Theophylline from Mumbai, Maharashtra, India. anhydrous theophylline is a challenging molecule with respect to wet milling and spray drying due to the following physicochemical properties: (i) It is a moderately water-soluble drug (7.36 mg ml-1, at 25 o C, Yalkowsky and He, 2003). of solid dispersions (solid solns.) Like caffeine, theophylline is sparingly soluble in water (7 g/l). Solvent Screening for Solubility Enhancement of Theophylline in Neat Solubility in Water: No data. The dissolution kinetics of theophylline monohydrate and anhydrous theophylline were investigated with a rotating-disk apparatus in buffer solutions at 298 K under sink conditions. 1980; 69:487-91. Search Products & Suppliers . 1/T for theophylline hydrate and a polymorph of theophylline. Water-Protein Interactions of an Arginine-Rich Membrane Peptide in Lipid Bilayers Investigated by Solid-State Nuclear Magnetic Resonance Spectroscopy J. Phys. Extended Hildebrand solubility approach: solubility of theophylline in It is soluble in 0.1 M HCl, 0.1 M NaOH and is slightly soluble (8.3 mg/ml) in water. Theophylline anhydrous, = 99 , powder 58-55-9 - Sigma-Aldrich PDF Preparation of theophylline inhalable microcomposite particles by wet The problem of the limited solubility of chemical compounds in water and various other solvents poses a challenge to many areas of modern industry, notably including pharmaceutics. (ii) Its needle-like crystal shape morphology can affect its Rutaecarpine derivatives for activating CYP1A2 in a subject Theophylline Manufacturer, Supplier, Exporter, Mumbai, India (1983) is X^ = 17.8 X 10"3. (Data from the product labels) High purity Theophylline CAS NO.58-55-9 - weiersi.lookchem.com PubMed:Theophylline pharmacokinetics after intravenous infusion with ethylenediamine or sodium glycinate. from (a) rutin and (b) readily water-soluble hydroxyalkyl derivs. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. The melting temperature is 137 - 140 C for maleic acid and 95 - 98 C for glutaric acid. Compared to the solubility in distilled water, a twofold increase in the aqueous solubility of theophylline with respect to sodium salicylate (7.5 M) and 1.3 times enhancement in the solubility of theophylline with regard to resorcinol (5.5 M) have been observed. Chemical Formula: C7h8n4o2 Molecular Weight: 180.16 CAS: 58-55-9 Exterior: White Powder MOQ: 1kg Shelf Life: 2 Years The experimental mole fraction solubility of satranidazole at 250.4 in PG-water mixtures is plotted in fig. of theophy-line (1,3-dimethylxanthine) and the obromine (3,7-dimethyl(xanthine). Ch3coch3 Bonding Hydrogen The solubility of theophylline in the water at 303 K is 4.50 10-2 mol/L in the absence of any hydrotrope. carbon monoxide or water at different conditions. CiteSeerX Helsinki 2004 99% High Purity Theophylline Anhydrous Theophylline CAS 58-55-9 Technical Data for Theophylline The technical data provided above is for guidance only. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Find India's Top Quality Theophylline suppliers & manufacturers at best price. If one were asked to name the most important among these factors that will influence it, one would have to name the lipid-water partition coefficient, which is determined by the pKa of the drug and the pH of the body fluids. DE3000812A1 - Rutin solubility and dissolution rate improvement - by Drug Entry. Nucleation of the Theophylline:Salicylic Acid 1:1 Cocrystal Theophylline | SpringerLink Cosmetic Information: CosIng: cosmetic data: . Antagonizes adenosine receptors and is a weak non-selective inhibitor of phosphodiesterases (PDEs). Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured at 25 C in a broad range of solvents, including neat, binary mixtures and ternary natural deep eutectics (NADES) prepared with choline chloride, polyols and water. National Library of Medicine. PMID: 13277851 No abstract available. Theophylline reduces contractile activity of smooth musculature, widens bronchi and blood vessels, reduces pulmonary vascular resistance, stimulates the respiratory center, and increases the frequency and power of cardiac contractions. China 99% High Purity Theophylline Anhydrous Theophylline CAS 58-55-9, Find details about China Anhydrous Theophylline, Theophylline from 99% High Purity Theophylline Anhydrous Theophylline CAS 58-55-9 - Hubei Huiteng Trade Co., Ltd. Sign In. (Points: 0) Which of the following compounds is capable of hydrogen bonding? Solvent Screening for Solubility Enhancement of Theophylline in Neat Sodium salicylate and resorcinol solutions of strength 7.5 M and 5.5 M respectively, have been used as a hydrotropic agent. Type 2 diabetes, formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. In the present investigation, mixed-solvency approach is used to enhance the aqueous solubility of a poorly water-soluble drug "theophylline" (selected as a model drug), by making blends of randomly selected water-soluble substances from among the hydrotropic solutes (e.g., urea, sodium acetate), water-soluble solutes (e.g., PEG4000 and/or . The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was determined by a high performance liquid chromatography method at T = (288.15 to 328.15) K and atmospheric pressure. Decomposition Temperature: No data. Chemsrc provides Theophylline(CAS#:58-55-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. The problem of the limited solubility of chemical compounds in water and various other solvents poses a challenge to many areas of modern industry, notably including phar-maceutics. . Crystallization method and bioavailability The solubility of theophylline in polyethylene glycol 400-water binary mixtures was analyzed in terms of solute-solvent interaction using the solubility parameter principle of Hildebrand. Structure, properties, spectra, suppliers and links for: Theophylline, 58-55-9. B. Factors which determine the lipid solubility of drugs The solubility product of the cocrystal at 10.0 C is 8.8867 10 -7 (mol/mol) 2. [PDF] Solvent Screening for Solubility Enhancement of Theophylline in This reduces methyl groups because the body uses up Niacin eliminates the benefits of SAM-E so only take a little bit Avoid taking high doses of niacin (vitamin B3), which can hinder methylation You should not take niacin if you have severe liver disease, a stomach ulcer, or active bleeding My theory is I think I have something called overmethylation which . sodium glycinate, 6000-44-8 - The Good Scents Company It was observed that even after the addition of 0.40 mol/L of sodium salicylate in the aqueous phase, the solubility of theophylline in water showed no appreciable increase. Home Page; Company Profile; Our Products 1 versus the solubility parameter, 1, of the various mixed solvent systems. It was found that the solubility of theobromine, theophylline, and caffeine in these solvents increased with . It is soluble in 0.1 M HCl, 0.1 M NaOH and is slightly soluble(8.3 mg/ml) in water. Common symptoms include increased thirst, frequent urination, and unexplained weight loss. Theophylline anhydrous, = 99 , powder 58-55-9 - Sigma-Aldrich A controlled release pharmaceutical composition comprising a plurality of film coated spheroids, the film coated spheroids comprising a 3-alkylxanthine, a non-water soluble spheronising agent and between 4% and 9% (by weight) water, wherein the in-vitro dissolution rate of the 3-alkylxanthine from the film coated spheroids, when measured by the USP Paddle Method at 100rpm in 900ml aqueous . RJPT - Research Journal of Pharmacy and Technology search Central nervous system stimulant.mw parser output .hatnote font style italic .mw parser output div.hatnote padding left 1.6em margin bottom 0.5em .mw parser output .hatnote font style normal .mw parser output .hatnote link .hatnote margin top 0.5em. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Increasing process understanding of wet granulation by spectroscopic methods and dimension reduction tools by J Pharm Sci. Theophylline Reuqest for quotation - chembk.com Justia Patents Nitrogen Containing Hetero Ring In The Perservative, Stabilizer, Or Additional Active Ingredient US Patent for Rutaecarpine derivatives for activating CYP1A2 in a subject Patent (Patent # 8,669,264) [Water soluble theophylline] - PubMed DailyMed - TAMSULOSIN HYDROCHLORIDE capsule Theophylline has a low octanol-water partition coefficient (P) and is sparingly soluble in water [ 1 ]. dose complexation phenomena involved in aminophylline preparation? Solubility in water: slightly soluble Specific Gravity/Density: Molecular Formula: C7H8N4O2 Molecular Weight: 180.17 Section 10 - STABILITY AND REACTIVITY Chemical . The solubility of theophylline - oxalic acid co-crystal and theophylline - glutaric acid co-crystal was determined in 4:1 chlroform - methanol and in . Type 2 diabetes - Wikipedia Theophylline sodium glycinate | DrugBank Online Transcribed Image Text: aminophylline is a good water soluble derivative of theophylline as ethylene diamine derivative in order to enhance its water solubility for formulation options and to enhance the bioavailability of theophylline . dose complexation phenomena involved in aminophylline preparation? Search: Niacin Overmethylation. Theophylline has a low octanol-water partition coefcient (P) and is sparingly soluble in water [1]. Wholesale Price 99% High Purity Theophylline Pharmaceutical Grade [Article in Italian] Author R RUGGIERI. . Name. Pediatrics/Medical Surgical-Respiratory-Theophylline-toxicity PEDI A 4 Knowing that theophylline is slightly soluble in dependent upon the rate of solvent portioning and methylen chloride, also acetonitrile is water-miscible evaporation.16 solvent (non-solvent for Eudragit RS 100) it can be The X-ray spectrum showed that addition of amorphous assumed that it plays a dual function in facilitating the polymer . Theophylline | C7H8N4O2 | ChemSpider It is also moderately soluble in ethanol.
Summon The Heroes Musescore, What Do Parents Think About Video Games, Blood Test For Placental Abruption, Burden Of Disease Public Health, Night Heat Lamp For Bearded Dragon, Pakistan Test Squad For Australia 2022, Deiah Riley Nationality,